Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.


Autoria(s): Veloso T.R.; Oechslin F.; Que Y.A.; Moreillon P.; Entenza J.M.; Mancini S.
Data(s)

2015

Resumo

Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.

Identificador

http://serval.unil.ch/?id=serval:BIB_61D89C363FF6

isbn:2049-632X (Electronic)

pmid:26310867

doi:10.1093/femspd/ftv060

isiid:000362978200005

Idioma(s)

en

Fonte

Pathogens and Disease, vol. 73, no. 8, pp. ftv060

Palavras-Chave #antiplatelets; prophylaxis; experimental endocarditis; Enterococcus faecalis; Streptococcus gallolyticus
Tipo

info:eu-repo/semantics/article

article