In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.
| Data(s) |
2015
|
|---|---|
| Resumo |
Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These results suggest that mecC-MRSA infections may successfully respond to treatment with β-lactams. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_1BCA842865A6 isbn:1098-6596 (Electronic) pmid:25605361 doi:10.1128/AAC.04733-14 isiid:000354993700075 |
| Idioma(s) |
en |
| Fonte |
Antimicrobial Agents and Chemotherapy, vol. 59, no. 4, pp. 2435-2438 |
| Tipo |
info:eu-repo/semantics/article article |
