Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome
| Contribuinte(s) |
Universitat de Barcelona |
|---|---|
| Resumo |
Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region. |
| Identificador | |
| Idioma(s) |
eng |
| Publicador |
Public Library of Science (PLoS) |
| Direitos |
cc-by (c) Rodriguez Frías, F. et al., 2012 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a> |
| Palavras-Chave | #Hepatitis B #Medicaments antivírics #Expressió gènica #Hepatitis B #Antiviral agents #Gene expression |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
