Isolation, structural assignment and total synthesis of Barmumycin


Autoria(s): Lorente, Adriana; Pla Queral, Daniel; Cañedo, Librada M.; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes
Data(s)

28/06/2014

Resumo

Barmumycin was isolated from an extract of the marine actinomycete Streptomyces sp. BOSC-022A and found to be cytotoxic against various human tumor cell lines. Based on preliminary one- and two-dimensional 1H- and 13C-NMR spectra, the natural compound was initially assigned the structure of macrolactone-type compound 1, which was later prepared by two different routes. However, major spectroscopic differences between isolated barmumycin and 1 led to revision of the proposed structure as E-16. Based on synthesis of this new compound, and subsequent spectroscopic comparison of it to an authentic sample of barmumycin, the structure of the natural compound was indeed confirmed as that of E-16.

Identificador

http://hdl.handle.net/2072/234266

Idioma(s)

eng

Publicador

American Chemical Society

Direitos

(c) American Chemical Society , 2010

info:eu-repo/semantics/openAccess

Palavras-Chave #Medicaments antineoplàstics #Productes naturals marins #Lactones #Antineoplastic agents #Marine natural products #Lactones
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/acceptedVersion