IRF-3 partners Bax in a viral-induced dance macabre.
| Data(s) |
2010
|
|---|---|
| Resumo |
In this issue of The EMBO Journal, Chattopadhyay et al (2010) describe a surprising new mechanism for how viral dsRNA detection by the RIG-I/MAVS signalling complex can initiate apoptosis. Independent of its transcriptional function, a pool of interferon regulatory factor (IRF)-3 activated downstream of MAVS can bind to and activate cytosolic Bax, resulting in Bax translocation to the mitochondria and initiation of the intrinsic apoptotic pathway. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_F9B90978C7AF isbn:1460-2075[electronic], 0261-4189[linking] pmid:20485298 doi:10.1038/emboj.2010.79 isiid:000277833100002 |
| Idioma(s) |
en |
| Fonte |
EMBO Journal, vol. 29, no. 10, pp. 1627-1628 |
| Palavras-Chave | #Apoptosis; Caspase 8/metabolism; Cytosol/metabolism; Cytosol/virology; DNA, Viral/genetics; Gene Expression Regulation; Gene Expression Regulation, Viral; Humans; Interferon Regulatory Factor-3/metabolism; Mitochondria/metabolism; Mitochondria/virology; Models, Biological; RNA, Double-Stranded/genetics; Transcription, Genetic; Viral Proteins/genetics; bcl-2-Associated X Protein/metabolism |
| Tipo |
info:eu-repo/semantics/article article |
