Guiding ligands to nuclear receptors.
| Data(s) |
2007
|
|---|---|
| Resumo |
Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_F90FCBBDF059 isbn:0092-8674 (Print) pmid:17512397 doi:10.1016/j.cell.2007.05.001 isiid:000246788300008 |
| Idioma(s) |
en |
| Fonte |
Cell, vol. 129, no. 4, pp. 649-651 |
| Palavras-Chave | #Active Transport, Cell Nucleus/physiology; Animals; Apoptosis/physiology; Cell Nucleus/metabolism; Cell Survival/physiology; Humans; Ligands; PPAR-beta/metabolism; Receptors, Retinoic Acid/metabolism; Signal Transduction/physiology; Tretinoin/metabolism |
| Tipo |
info:eu-repo/semantics/article article |
