Pauson-Khand Adducts of N-Boc-propargylamine: A New Approach to 4,5-Disubstituted Cyclopentenones
| Data(s) |
13/05/2014
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| Resumo |
A new approach to the synthesis of 4,5-disubstituted cyclopentenones is described. The strategy is based on the Pauson-Khand (PK) reaction of norbornadiene and N-Boc-propargylamine as alkyne with a masked leaving group, which can be eliminated at will. This approach to the synthesis of 4,5-disubstituted cyclopentenones overcomes the problem of using the alkylation to introduce the alpha-side-chain. As an example, prostane 13-epi-12-oxo-phytodienoic acid (13-epi-12-oxo-PDA) methyl ester was synthesized. |
| Identificador | |
| Idioma(s) |
eng |
| Publicador |
American Chemical Society |
| Direitos |
(c) American Chemical Society , 2013 info:eu-repo/semantics/embargoedAccess |
| Palavras-Chave | #Ciclització (Química) #Química biorgànica #Compostos orgànics #Síntesi orgànica #Hormones #Efecte de l'estrès sobre les plantes #Estrès (Psicologia) #Prostaglandines #Biomolècules #Ring formation (Chemistry) #Bioorganic chemistry #Organic compounds #Organic synthesis #Hormones #Effect of stress on plants #Stress (Psychology) #Prostaglandins #Biomolecules |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
