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**Autoria(s):** Bovine Genome Sequencing; Analysis Consortium; Elsik C.G.; Tellam R.L.; Worley K.C.; Gibbs R.A.; Muzny D.M.; Weinstock G.M.; Adelson D.L.; Eichler E.E.; Elnitski L.; GuigÃ³ R.; Hamernik D.L.; Kappes S.M.; Lewin H.A.; Lynn D.J.; Nicholas F.W.; Reymond A.; Rijnkels M.; Skow L.C.; Zdobnov E.M.; Schook L.; Womack J.; Alioto T.; Antonarakis S.E.; Astashyn A.; Chapple C.E.; Chen H.C.; Chrast J.; CÃ¢mara F.; Ermolaeva O.; Henrichsen C.N.; Hlavina W.; Kapustin Y.; Kiryutin B.; Kitts P.; Kokocinski F.; Landrum M.; Maglott D.; Pruitt K.; Sapojnikov V.; Searle S.M.; Solovyev V.; Souvorov A.; Ucla C.; Wyss C.; Anzola J.M.; Gerlach D.; Elhaik E.; Graur D.; Reese J.T.; Edgar R.C.; McEwan J.C.; Payne G.M.; Raison J.M.; Junier T.; Kriventseva E.V.; Eyras E.; Plass M.; Donthu R.; Larkin D.M.; Reecy J.; Yang M.Q.; Chen L.; Cheng Z.; Chitko-McKown C.G.; Liu G.E.; Matukumalli L.K.; Song J.; Zhu B.; Bradley D.G.; Brinkman F.S.; Lau L.P.; Whiteside M.D.; Walker A.; Wheeler T.T.; Casey T.; German J.B.; Lemay D.G.; Maqbool N.J.; Molenaar A.J.; Seo S.; Stothard P.; Baldwin C.L.; Baxter R.; Brinkmeyer-Langford C.L.; Brown W.C.; Childers C.P.; Connelley T.; Ellis S.A.; Fritz K.; Glass E.J.; Herzig C.T.; Iivanainen A.; Lahmers K.K.; Bennett A.K.; Dickens C.M.; Gilbert J.G.; Hagen D.E.; Salih H.; Aerts J.; Caetano A.R.; Dalrymple B.; Garcia J.F.; Gill C.A.; Hiendleder S.G.; Memili E.; Spurlock D.; Williams J.L.; Alexander L.; Brownstein M.J.; Guan L.; Holt R.A.; Jones S.J.; Marra M.A.; Moore R.; Moore S.S.; Roberts A.; Taniguchi M.; Waterman R.C.; Chacko J.; Chandrabose M.M.; Cree A.; Dao M.D.; Dinh H.H.; Gabisi R.A.; Hines S.; Hume J.; Jhangiani S.N.; Joshi V.; Kovar C.L.; Lewis L.R.; Liu Y.S.; Lopez J.; Morgan M.B.; Nguyen N.B.; Okwuonu G.O.; Ruiz S.J.; Santibanez J.; Wright R.A.; Buhay C.; Ding Y.; Dugan-Rocha S.; Herdandez J.; Holder M.; Sabo A.; Egan A.; Goodell J.; Wilczek-Boney K.; Fowler G.R.; Hitchens M.E.; Lozado R.J.; Moen C.; Steffen D.; Warren J.T.; Zhang J.; Chiu R.; Schein J.E.; Durbin K.J.; Havlak P.; Jiang H.; Liu Y.; Qin X.; Ren Y.; Shen Y.; Song H.; Bell S.N.; Davis C.; Johnson A.J.; Lee S.; Nazareth L.V.; Patel B.M.; Pu L.L.; Vattathil S.; Williams R.L.; Curry S.; Hamilton C.; Sodergren E.; Wheeler D.A.; Barris W.; Bennett G.L.; Eggen A.; Green R.D.; Harhay G.P.; Hobbs M.; Jann O.; Keele J.W.; Kent M.P.; Lien S.; McKay S.D.; McWilliam S.; Ratnakumar A.; Schnabel R.D.; Smith T.; Snelling W.M.; Sonstegard T.S.; Stone R.T.; Sugimoto Y.; Takasuga A.; Taylor J.F.; Van Tassell C.P.; Macneil M.D.; Abatepaulo A.R.; Abbey C.A.; Ahola V.; Almeida I.G.; Amadio A.F.; Anatriello E.; Bahadue S.M.; Biase F.H.; Boldt C.R.; Carroll J.A.; Carvalho W.A.; Cervelatti E.P.; Chacko E.; Chapin J.E.; Cheng Y.; Choi J.; Colley A.J.; de Campos T.A.; De Donato M.; Santos I.K.; de Oliveira C.J.; Deobald H.; Devinoy E.; Donohue K.E.; Dovc P.; Eberlein A.; Fitzsimmons C.J.; Franzin A.M.; Garcia G.R.; Genini S.; Gladney C.J.; Grant J.R.; Greaser M.L.; Green J.A.; Hadsell D.L.; Hakimov H.A.; Halgren R.; Harrow J.L.; Hart E.A.; Hastings N.; Hernandez M.; Hu Z.L.; Ingham A.; Iso-Touru T.; Jamis C.; Jensen K.; Kapetis D.; Kerr T.; Khalil S.S.; Khatib H.; Kolbehdari D.; Kumar C.G.; Kumar D.; Leach R.; Lee J.C.; Li C.; Logan K.M.; Malinverni R.; Marques E.; Martin W.F.; Martins N.F.; Maruyama S.R.; Mazza R.; McLean K.L.; Medrano J.F.; Moreno B.T.; MorÃ© D.D.; Muntean C.T.; Nandakumar H.P.; Nogueira M.F.; Olsaker I.; Pant S.D.; Panzitta F.; Pastor R.C.; Poli M.A.; Poslusny N.; Rachagani S.; Ranganathan S.; Razpet A.; Riggs P.K.; Rincon G.; Rodriguez-Osorio N.; Rodriguez-Zas S.L.; Romero N.E.; Rosenwald A.; Sando L.; Schmutz S.M.; Shen L.; Sherman L.; Southey B.R.; Lutzow Y.S.; Sweedler J.V.; Tammen I.; Telugu B.P.; Urbanski J.M.; Utsunomiya Y.T.; Verschoor C.P.; Waardenberg A.J.; Wang Z.; Ward R.; Weikard R.; Welsh T.H.; White S.N.; Wilming L.G.; Wunderlich K.R.; Yang J.; Zhao F.Q.
Data(s)	2009
Resumo	To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Identificador	http://serval.unil.ch/?id=serval:BIB_EE8C1C9D9ECA isbn:1095-9203[electronic], 0036-8075[linking] pmid:19390049 doi:10.1126/science.1169588 isiid:000265411200050
Idioma(s)	en
Fonte	Science, vol. 324, no. 5926, pp. 522-528
Palavras-Chave	#Alternative Splicing; Animals; Animals, Domestic; Cattle; Evolution; Evolution, Molecular; Female; Genetic Variation; Genome; Humans; Male; MicroRNAs/genetics; Molecular Sequence Data; Proteins/genetics; Sequence Analysis, DNA; Species Specificity; Synteny
Tipo	info:eu-repo/semantics/article article

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