Prospective determination of plasma imipenem concentrations in critically ill children.
| Data(s) |
2006
|
|---|---|
| Resumo |
Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4x at peak and >10x at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_E2F1AB540BD5 isbn:0066-4804[print], 0066-4804[linking] pmid:16801447 doi:10.1128/AAC.01149-05 isiid:000238721200046 |
| Idioma(s) |
en |
| Fonte |
Antimicrobial Agents and Chemotherapy, vol. 50, no. 7, pp. 2563-2568 |
| Palavras-Chave | #Anti-Bacterial Agents/administration & dosage; Area Under Curve; Bacterial Infections/drug therapy; Bacterial Infections/microbiology; Child; Child, Preschool; Cilastatin/administration & dosage; Critical Illness; Cross Infection/drug therapy; Cross Infection/microbiology; Drug Combinations; Drug Therapy, Combination; Female; Humans; Imipenem/administration & dosage; Imipenem/pharmacokinetics; Infant; Infant, Newborn; Infusions, Intravenous; Male |
| Tipo |
info:eu-repo/semantics/article article |
