Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
| Data(s) |
2008
|
|---|---|
| Resumo |
Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_E2D1A8A9A1D3 isbn:0066-4804[print], 0066-4804[linking] pmid:17999969 doi:10.1128/AAC.00939-07 isiid:000252133700039 |
| Idioma(s) |
en |
| Fonte |
Antimicrobial Agents and Chemotherapy, vol. 52, no. 1, pp. 337-339 |
| Palavras-Chave | #Anti-Bacterial Agents/pharmacology; Microbial Sensitivity Tests; Mutation; Penicillin Resistance/genetics; Penicillins/pharmacology; Selection, Genetic; Serial Passage; Streptococcus gordonii/drug effects; Streptococcus gordonii/genetics |
| Tipo |
info:eu-repo/semantics/article article |
