Seal properties of TachoSil: in vitro hemodynamic measurements.
Data(s) |
2010
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Resumo |
Fibrin glue products and collagen patches are frequently used as a sealing product, preventing surgical side bleedings. This is especially true in the field of cardiovascular surgery, where increasing numbers of patients are being operated with antiplatelet and anticoagulation therapy. The aim of this report was, in an in vitro hemodynamic setting, to examine the sealant properties of the TachoSil (Nycomed Pharma, Linz, Austria) patch. Burst pressure and normal force of 15 TachoSil sealed defects were measured. This was determined in a closed hydraulic system. Mean burst pressure load for a 5-mm defect was 69+/-11.4 mmHg; for a 7-mm defect was 63+/-16 mmHg; and, 62+/-16 mmHg for the defect with a diameter of 10 mm (P>0.05). The mean calculated normal force was as follows: 0.91+/-0.15 N for the 5 mm defect, 6.5+/-1.6 N for the 7 mm, and 8.1+/-0.75 N for the 10 mm defect. The TachoSil patch has the capability to seal small defects. However, at the larger defects the seal character was significantly reduced. These results suggest that the device may be a good alternative for hemostasis for small defects. The capacity to curtail or stop hemorrhage at the larger defects is unlikely. |
Identificador |
https://serval.unil.ch/?id=serval:BIB_DF0D2165CEF1 isbn:1569-9285[electronic], 1569-9285[linking] pmid:20354036 doi:10.1510/icvts.2010.235127 isiid:000208481800024 |
Idioma(s) |
en |
Fonte |
Interactive Cardiovascular and Thoracic Surgery, vol. 10, no. 6, pp. 910-913 |
Palavras-Chave | #Blood Loss, Surgical/physiopathology; Blood Loss, Surgical/prevention & control; Drug Combinations; Equipment Failure; Equipment Failure Analysis; Fibrin Tissue Adhesive/therapeutic use; Fibrinogen/therapeutic use; Hemodynamics; Hemostatic Techniques/instrumentation; Hemostatics/therapeutic use; Humans; Hydrostatic Pressure; Materials Testing; Postoperative Hemorrhage/physiopathology; Postoperative Hemorrhage/prevention & control; Surgical Sponges; Thrombin/therapeutic use |
Tipo |
info:eu-repo/semantics/article article |