Biblioteca Digital

**Autoria(s):** Rietveld C.A.; Medland S.E.; Derringer J.; Yang J.; Esko T.; Martin N.W.; Westra H.J.; Shakhbazov K.; Abdellaoui A.; Agrawal A.; Albrecht E.; Alizadeh B.Z.; Amin N.; Barnard J.; Baumeister S.E.; Benke K.S.; Bielak L.F.; Boatman J.A.; Boyle P.A.; Davies G.; de Leeuw C.; Eklund N.; Evans D.S.; Ferhmann R.; Fischer K.; Gieger C.; Gjessing H.K.; Hägg S.; Harris J.R.; Hayward C.; Holzapfel C.; Ibrahim-Verbaas C.A.; Ingelsson E.; Jacobsson B.; Joshi P.K.; Jugessur A.; Kaakinen M.; Kanoni S.; Karjalainen J.; Kolcic I.; Kristiansson K.; Kutalik Z.; Lahti J.; Lee S.H.; Lin P.; Lind P.A.; Liu Y.; Lohman K.; Loitfelder M.; McMahon G.; Vidal P.M.; Meirelles O.; Milani L.; Myhre R.; Nuotio M.L.; Oldmeadow C.J.; Petrovic K.E.; Peyrot W.J.; Polasek O.; Quaye L.; Reinmaa E.; Rice J.P.; Rizzi T.S.; Schmidt H.; Schmidt R.; Smith A.V.; Smith J.A.; Tanaka T.; Terracciano A.; van der Loos M.J.; Vitart V.; Völzke H.; Wellmann J.; Yu L.; Zhao W.; Allik J.; Attia J.R.; Bandinelli S.; Bastardot F.; Beauchamp J.; Bennett D.A.; Berger K.; Bierut L.J.; Boomsma D.I.; Bültmann U.; Campbell H.; Chabris C.F.; Cherkas L.; Chung M.K.; Cucca F.; de Andrade M.; De Jager P.L.; De Neve J.E.; Deary I.J.; Dedoussis G.V.; Deloukas P.; Dimitriou M.; Eiríksdóttir G.; Elderson M.F.; Eriksson J.G.; Evans D.M.; Faul J.D.; Ferrucci L.; Garcia M.E.; Grönberg H.; Guðnason V.; Hall P.; Harris J.M.; Harris T.B.; Hastie N.D.; Heath A.C.; Hernandez D.G.; Hoffmann W.; Hofman A.; Holle R.; Holliday E.G.; Hottenga J.J.; Iacono W.G.; Illig T.; Järvelin M.R.; Kähönen M.; Kaprio J.; Kirkpatrick R.M.; Kowgier M.; Latvala A.; Launer L.J.; Lawlor D.A.; Lehtimäki T.; Li J.; Lichtenstein P.; Lichtner P.; Liewald D.C.; Madden P.A.; Magnusson P.K.; Mäkinen T.E.; Masala M.; McGue M.; Metspalu A.; Mielck A.; Miller M.B.; Montgomery G.W.; Mukherjee S.; Nyholt D.R.; Oostra B.A.; Palmer L.J.; Palotie A.; Penninx B.W.; Perola M.; Peyser P.A.; Preisig M.; Räikkönen K.; Raitakari O.T.; Realo A.; Ring S.M.; Ripatti S.; Rivadeneira F.; Rudan I.; Rustichini A.; Salomaa V.; Sarin A.P.; Schlessinger D.; Scott R.J.; Snieder H.; St Pourcain B.; Starr J.M.; Sul J.H.; Surakka I.; Svento R.; Teumer A.; LifeLines Cohort Study; Tiemeier H.; Tiemeier H.; van Rooij F.J.; Van Wagoner D.R.; Vartiainen E.; Viikari J.; Vollenweider P.; Vonk J.M.; Waeber G.; Weir D.R.; Wichmann H.E.; Widen E.; Willemsen G.; Wilson J.F.; Wright A.F.; Conley D.; Davey-Smith G.; Franke L.; Groenen P.J.; Hofman A.; Johannesson M.; Kardia S.L.; Krueger R.F.; Laibson D.; Martin N.G.; Meyer M.N.; Posthuma D.; Thurik A.R.; Timpson N.J.; Uitterlinden A.G.; van Duijn C.M.; Visscher P.M.; Benjamin D.J.; Cesarini D.; Koellinger P.D.
Data(s)	2013
Resumo	A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
Identificador	https://serval.unil.ch/?id=serval:BIB_DE32A3661286 isbn:1095-9203 (Electronic) pmid:23722424 doi:10.1126/science.1235488 isiid:000320647000046
Idioma(s)	en
Fonte	Science, vol. 340, no. 6139, pp. 1467-1471
Palavras-Chave	#Cognition; Educational Status; Endophenotypes; Female; Genetic Loci; Genome-Wide Association Study; Humans; Male; Multifactorial Inheritance; Polymorphism, Single Nucleotide
Tipo	info:eu-repo/semantics/article article

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