Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Autoria(s): Wain L.V.; Verwoert G.C.; O'Reilly P.F.; Shi G.; Johnson T.; Johnson A.D.; Bochud M.; Rice K.M.; Henneman P.; Smith A.V.; Ehret G.B.; Amin N.; Larson M.G.; Mooser V.; Hadley D.; Dörr M.; Bis J.C.; Aspelund T.; Esko T.; Janssens A.C.; Zhao J.H.; Heath S.; Laan M.; Fu J.; Pistis G.; Luan J.; Arora P.; Lucas G.; Pirastu N.; Pichler I.; Jackson A.U.; Webster R.J.; Zhang F.; Peden J.F.; Schmidt H.; Tanaka T.; Campbell H.; Igl W.; Milaneschi Y.; Hottenga J.J.; Vitart V.; Chasman D.I.; Trompet S.; Bragg-Gresham J.L.; Alizadeh B.Z.; Chambers J.C.; Guo X.; Lehtimäki T.; Kühnel B.; Lopez L.M.; Pola?ek O.; Boban M.; Nelson C.P.; Morrison A.C.; Pihur V.; Ganesh S.K.; Hofman A.; Kundu S.; Mattace-Raso F.U.; Rivadeneira F.; Sijbrands E.J.; Uitterlinden A.G.; Hwang S.J.; Vasan R.S.; Wang T.J.; Bergmann S.; Vollenweider P.; Waeber G.; Laitinen J.; Pouta A.; Zitting P.; McArdle W.L.; Kroemer H.K.; Völker U.; Völzke H.; Glazer N.L.; Taylor K.D.; Harris T.B.; Alavere H.; Haller T.; Keis A.; Tammesoo M.L.; Aulchenko Y.; Barroso I.; Khaw K.T.; Galan P.; Hercberg S.; Lathrop M.; Eyheramendy S.; Org E.; Sõber S.; Lu X.; Nolte I.M.; Penninx B.W.; Corre T.; Masciullo C.; Sala C.; Groop L.; Voight B.F.; Melander O.; O'Donnell C.J.; Salomaa V.; d'Adamo A.P.; Fabretto A.; Faletra F.; Ulivi S.; Del Greco M F.; Facheris M.; Collins F.S.; Bergman R.N.; Beilby J.P.; Hung J.; Musk A.W.; Mangino M.; Shin S.Y.; Soranzo N.; Watkins H.; Goel A.; Hamsten A.; Gider P.; Loitfelder M.; Zeginigg M.; Hernandez D.; Najjar S.S.; Navarro P.; Wild S.H.; Corsi A.M.; Singleton A.; de Geus E.J.; Willemsen G.; Parker A.N.; Rose L.M.; Buckley B.; Stott D.; Orru M.; Uda M.; van der Klauw M.M.; Zhang W.; Li X.; Scott J.; Chen Y.D.; Burke G.L.; Kähönen M.; Viikari J.; Döring A.; Meitinger T.; Davies G.; Starr J.M.; Emilsson V.; Plump A.; Lindeman J.H.; Hoen P.A.; König I.R.; Felix J.F.; Clarke R.; Hopewell J.C.; Ongen H.; Breteler M.; Debette S.; Destefano A.L.; Fornage M.; Mitchell G.F.; Smith N.L.; Holm H.; Stefansson K.; Thorleifsson G.; Thorsteinsdottir U.; Samani N.J.; Preuss M.; Rudan I.; Hayward C.; Deary I.J.; Wichmann H.E.; Raitakari O.T.; Palmas W.; Kooner J.S.; Stolk R.P.; Jukema J.W.; Wright A.F.; Boomsma D.I.; Bandinelli S.; Gyllensten U.B.; Wilson J.F.; Ferrucci L.; Schmidt R.; Farrall M.; Spector T.D.; Palmer L.J.; Tuomilehto J.; Pfeufer A.; Gasparini P.; Siscovick D.; Altshuler D.; Loos R.J.; Toniolo D.; Snieder H.; Gieger C.; Meneton P.; Wareham N.J.; Oostra B.A.; Metspalu A.; Launer L.; Rettig R.; Strachan D.P.; Beckmann J.S.; Witteman J.C.; Erdmann J.; van Dijk K.W.; Boerwinkle E.; Boehnke M.; Ridker P.M.; Jarvelin M.R.; Chakravarti A.; Abecasis G.R.; Gudnason V.; Newton-Cheh C.; Levy D.; Munroe P.B.; Psaty B.M.; Caulfield M.J.; Rao D.C.; Tobin M.D.; Elliott P.; van Duijn C.M.; LifeLines Cohort Study; EchoGen consortium; AortaGen Consortium; CHARGE Consortium Heart Failure Working Group; KidneyGen consortium; CKDGen consortium; Cardiogenics consortium; CardioGram
Data(s)

2011
Resumo

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Identificador

https://serval.unil.ch/?id=serval:BIB_DBEEF95D2F27

isbn:1546-1718 (Electronic)

pmid:21909110

doi:10.1038/ng.922

isiid:000295316200017
Idioma(s)

en
Direitos

info:eu-repo/semantics/openAccess
Fonte

Nature Genetics, vol. 43, no. 10, pp. 1005-1011
Palavras-Chave #Arteries/metabolism; Blood Pressure/genetics; Case-Control Studies; Follow-Up Studies; Genetic Loci; Genome-Wide Association Study; Humans; Hypertension/genetics; Linkage Disequilibrium; Polymorphism, Single Nucleotide
Tipo

info:eu-repo/semantics/article

article
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