Basic calcium phosphate crystals induce IL-1B secretion in vitro through activation of the Nalp3 inflammasome

Autoria(s): Pazar B.; Busso N.; Kolly L.; Narayan S.; Bagnoud N.; Chobaz V.; Ea H.O.; Lioté F.; Yazdi A.; Tschopp J.; So A.
Data(s)

2010
Resumo

Objectives: We tested the effects of the three forms of basic calcium phosphate (BCP) crystals (octacalcium phosphate (OCP), carbonate-substituted apatite (CA) and hydroxyapatite (HA)) on monocytes and macrophages on IL-1β secretion. The requirement for the NALP3 inflammasome and TLR2 and TLR4 receptors in this acute response was analyzed.
Identificador

http://serval.unil.ch/?id=serval:BIB_D9C954BC4787

isbn:0003-4967
Idioma(s)

en
Fonte

EULAR 2010, Annual European Congress of Rheumatology
Tipo

info:eu-repo/semantics/conferenceObject

inproceedings
Acesso ao item digital