Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.

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Autoria(s): Romano E.; Rossi M.; Ratzinger G.; de Cos M.A.; Chung D.J.; Panageas K.S.; Wolchok J.D.; Wolchock J.D.; Houghton A.N.; Chapman P.B.; Heller G.; Yuan J.; Young J.W.

Data(s)	2011
Identificador	http://serval.unil.ch/?id=serval:BIB_D910A818B30C isbn:1078-0432 (Print) pmid:21355077 doi:10.1158/1078-0432.CCR-10-3421 isiid:000289054100036
Idioma(s)	en
Fonte	Clinical Cancer Research, vol. 17, no. 7, pp. 1984-1997
Palavras-Chave	#Adult; Aged; Aged, 80 and over; Antigens, CD3/metabolism; Antigens, CD8/metabolism; Antigens, Neoplasm/immunology; Apoptosis/drug effects; Cancer Vaccines/adverse effects; Cancer Vaccines/therapeutic use; Dendritic Cells/drug effects; Dendritic Cells/immunology; Drug Synergism; Erythema/etiology; Female; HLA-A Antigens/metabolism; Humans; Immunotherapy, Active; Interferon-gamma/secretion; Interleukin-15/immunology; Interleukin-15/pharmacology; Interleukin-2/immunology; Interleukin-2/pharmacology; Langerhans Cells/drug effects; Langerhans Cells/immunology; Lymphocyte Activation; Male; Melanoma/immunology; Melanoma/therapy; Middle Aged; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Cytotoxic/physiology; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/physiology
Tipo	info:eu-repo/semantics/article article