Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains.
| Data(s) |
2013
|
|---|---|
| Resumo |
Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_D835D632579F isbn:1873-2518 (Electronic) pmid:23313617 doi:10.1016/j.vaccine.2012.12.076 isiid:000315312600008 |
| Idioma(s) |
en |
| Fonte |
Vaccine, vol. 31, no. 9, pp. 1298-1304 |
| Palavras-Chave | #Sabin IPV; Oil-in water; PagL; AlOH3; Replicon particles; MPL |
| Tipo |
info:eu-repo/semantics/article article |
