CD8+ T cell development: CD4 to the rescue.
| Data(s) |
2001
|
|---|---|
| Resumo |
How immature CD4+CD8+ thymocytes become committed to either the CD4 (helper) or CD8 (cytotoxic) lineage is controversial. Genetic ablation of a silencer element in the gene encoding CD4 provides new evidence that CD8 lineage commitment occurs via a stochastic, rather than instructive, mechanism. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_D6E291A0A03B isbn:1529-2908 (Print) pmid:11725294 doi:10.1038/ni1201-1091 isiid:000172473200006 |
| Idioma(s) |
en |
| Fonte |
Nature Immunology, vol. 2, no. 12, pp. 1091-1092 |
| Palavras-Chave | #Animals; Antigens, CD4/genetics; Antigens, CD4/metabolism; Cell Lineage; Gene Silencing; Mice; Models, Immunological; Regulatory Sequences, Nucleic Acid; Stochastic Processes; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Helper-Inducer/immunology; Thymus Gland/immunology |
| Tipo |
info:eu-repo/semantics/article article |
