Experimental cutaneous Leishmaniasis: a powerful model to study in vivo the mechanisms underlying genetic differences in Th subset differentiation.


Autoria(s): Louis J.; Gumy A.; Voigt H.; Röcken M.; Launois P.
Data(s)

2002

Resumo

The murine model of infection with Leishmania major has allowed the demonstration in vivo of the importance CD4+ T cell subsets, distinguishable by the pattern of cytokines they produce, on the outcome of infectious diseases. Genetically determined resistance and susceptibility to infection with this parasite are the result of the development of Th1 and Th2 response, respectively. In this short paper, we present some results obtained in our group pertaining to the analysis of the mechanisms, operational during the early phase of this infection, responsible for the maturation of these functionally distinct CD4+ responses.

Identificador

http://serval.unil.ch/?id=serval:BIB_D07892DB76AE

isbn:1167-1122 (Print)

pmid:12095873

isiid:000176529500002

Idioma(s)

en

Fonte

European Journal of Dermatology, vol. 12, no. 4, pp. 316-318

Palavras-Chave #Animals; CD4-Positive T-Lymphocytes/immunology; Cell Differentiation; Disease Models, Animal; Immunity, Innate/genetics; Interleukin-4/immunology; Leishmania major/genetics; Leishmania major/immunology; Leishmaniasis, Cutaneous/genetics; Leishmaniasis, Cutaneous/immunology; Mice; Mice, Inbred BALB C/genetics
Tipo

info:eu-repo/semantics/review

article