In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.


Autoria(s): Speiser D.E.; Pittet M.J.; Valmori D.; Dunbar R.; Rimoldi D.; Liénard D.; MacDonald H.R.; Cerottini J.C.; Cerundolo V.; Romero P.
Data(s)

1999

Resumo

Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo.

Identificador

https://serval.unil.ch/?id=serval:BIB_CDA12DB53A1D

isbn:0022-1007

pmid:10499916

doi:10.1084/jem.190.6.775

isiid:000082813900004

http://my.unil.ch/serval/document/BIB_CDA12DB53A1D.pdf

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_CDA12DB53A1D2

Idioma(s)

en

Direitos

info:eu-repo/semantics/openAccess

Fonte

The Journal of experimental medicine, vol. 190, no. 6, pp. 775-782

Palavras-Chave #Antigens, CD/immunology; Antigens, Neoplasm/immunology; Cytotoxicity, Immunologic; Flow Cytometry; Humans; Killer Cells, Natural/immunology; Lectins, C-Type; Melanoma/immunology; Membrane Glycoproteins/immunology; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Receptors, Antigen, T-Cell/immunology; Receptors, Immunologic/immunology; Receptors, Natural Killer Cell; T-Lymphocytes, Cytotoxic/immunology
Tipo

info:eu-repo/semantics/article

article