Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Autoria(s): Lindgren C.M.; Heid I.M.; Randall J.C.; Lamina C.; Steinthorsdottir V.; Qi L.; Speliotes E.K.; Thorleifsson G.; Willer C.J.; Herrera B.M.; Jackson A.U.; Lim N.; Scheet P.; Soranzo N.; Amin N.; Aulchenko Y.S.; Chambers J.C.; Drong A.; Luan J.; Lyon H.N.; Rivadeneira F.; Sanna S.; Timpson N.J.; Zillikens M.C.; Zhao J.H.; Almgren P.; Bandinelli S.; Bennett A.J.; Bergman R.N.; Bonnycastle L.L.; Bumpstead S.J.; Chanock S.J.; Cherkas L.; Chines P.; Coin L.; Cooper C.; Crawford G.; Doering A.; Dominiczak A.; Doney A.S.; Ebrahim S.; Elliott P.; Erdos M.R.; Estrada K.; Ferrucci L.; Fischer G.; Forouhi N.G.; Gieger C.; Grallert H.; Groves C.J.; Grundy S.; Guiducci C.; Hadley D.; Hamsten A.; Havulinna A.S.; Hofman A.; Holle R.; Holloway J.W.; Illig T.; Isomaa B.; Jacobs L.C.; Jameson K.; Jousilahti P.; Karpe F.; Kuusisto J.; Laitinen J.; Lathrop G.M.; Lawlor D.A.; Mangino M.; McArdle W.L.; Meitinger T.; Morken M.A.; Morris A.P.; Munroe P.; Narisu N.; Nordström A.; Nordström P.; Oostra B.A.; Palmer C.N.; Payne F.; Peden J.F.; Prokopenko I.; Renström F.; Ruokonen A.; Salomaa V.; Sandhu M.S.; Scott L.J.; Scuteri A.; Silander K.; Song K.; Yuan X.; Stringham H.M.; Swift A.J.; Tuomi T.; Uda M.; Vollenweider P.; Waeber G.; Wallace C.; Walters G.B.; Weedon M.N.; Witteman J.C.; Witteman J.C.; Zhang C.; Zhang W.; Caulfield M.J.; Collins F.S.; Davey Smith G.; Day I.N.; Franks P.W.; Hattersley A.T.; Hu F.B.; Jarvelin M.R.; Kong A.; Kooner J.S.; Laakso M.; Lakatta E.; Mooser V.; Morris A.D.; Peltonen L.; Samani N.J.; Spector T.D.; Strachan D.P.; Tanaka T.; Tuomilehto J.; Uitterlinden A.G.; van Duijn C.M.; Wareham N.J.; Hugh Watkins D.M.; Waterworth D.M.; Waterworth D.M.; Boehnke M.; Deloukas P.; Groop L.; Hunter D.J.; Thorsteinsdottir U.; Schlessinger D.; Wichmann H.E.; Frayling T.M.; Abecasis G.R.; Hirschhorn J.N.; Loos R.J.; Stefansson K.; Mohlke K.L.; Barroso I.; McCarthy M.I.
Data(s)

2009
Resumo

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
Identificador

https://serval.unil.ch/?id=serval:BIB_C2EFFD956BB3

isbn:1553-7404[electronic]

pmid:19557161

doi:10.1371/journal.pgen.1000508

isiid:000268444600004

http://my.unil.ch/serval/document/BIB_C2EFFD956BB3.pdf

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_C2EFFD956BB30
Idioma(s)

en
Direitos

info:eu-repo/semantics/openAccess
Fonte

PLoS Genetics, vol. 5, no. 6, pp. e1000508
Tipo

info:eu-repo/semantics/article

article
Acesso ao item digital