P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases.

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Autoria(s): Kuemmerle A.; Yan H.; Krueger T.; Buclin T.; Braissant O.; Henry H.; Ris H.B.; Decosterd L.A.

Data(s)	2011
Identificador	https://serval.unil.ch/?id=serval:BIB_B8D0A4E8CC76 isbn:1791-7530 (Electronic) pmid:21737631 isiid:000292631300015 doi:
Idioma(s)	en
Fonte	Anticancer Research, vol. 31, no. 6, pp. 2121-2128
Palavras-Chave	#Animals; Antibiotics, Antineoplastic/pharmacokinetics; Chemotherapy, Cancer, Regional Perfusion; Cyclosporine/blood; Cyclosporine/pharmacology; Cyclosporins/pharmacology; Doxorubicin/administration & dosage; Doxorubicin/pharmacokinetics; Drug Interactions; Lung Neoplasms/drug therapy; Lung Neoplasms/metabolism; Male; P-Glycoprotein/biosynthesis; P-Glycoprotein/metabolism; Rats; Rats, Inbred F344; Sarcoma/drug therapy; Sarcoma/metabolism
Tipo	info:eu-repo/semantics/article article