Efavirenz intoxication due to a new CYP2B6 constellation.
| Data(s) |
2013
|
|---|---|
| Resumo |
Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_B791CC3A33EA isbn:2040-2058 (Electronic) pmid:23640958 doi:10.3851/IMP2571 isiid:000329761700013 |
| Idioma(s) |
en |
| Fonte |
Antiviral Therapy, vol. 18, no. 5, pp. 739-743 |
| Tipo |
info:eu-repo/semantics/article article |
