CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes.

Autoria(s): Mukhopadhyay P.; Rajesh M.; Bátkai S.; Patel V.; Kashiwaya Y.; Liaudet L.; Evgenov O.V.; Mackie K.; Haskó G.; Pacher P.
Data(s)

2010
Identificador

https://serval.unil.ch/?id=serval:BIB_B3A5C856592D

isbn:1755-3245[electronic], 0008-6363[linking]

doi:10.1093/cvr/cvp369

pmid:19942623

isiid:000274487900017
Idioma(s)

en
Fonte

Cardiovascular Research, vol. 85, no. 4, pp. 773-784
Palavras-Chave #Amidohydrolases/metabolism; Animals; Antibiotics, Antineoplastic/toxicity; Apoptosis/physiology; Cardiomyopathies/chemically induced; Cardiomyopathies/metabolism; Caspase 3/metabolism; Caspase 7/metabolism; Cells, Cultured; Cytochromes c/metabolism; Disease Models, Animal; Doxorubicin/toxicity; Endocannabinoids/metabolism; Endomyocardial Fibrosis/chemically induced; Endomyocardial Fibrosis/metabolism; Humans; MAP Kinase Signaling System/physiology; Male; Mice; Mice, Knockout; Myocytes, Cardiac/cytology; Myocytes, Cardiac/metabolism; Oxidative Stress/physiology; Poly(ADP-ribose) Polymerases/metabolism; Reactive Nitrogen Species/metabolism; Reactive Oxygen Species/metabolism; Receptor, Cannabinoid, CB1/genetics; Receptor, Cannabinoid, CB1/metabolism; Ventricular Function, Left/physiology
Tipo

info:eu-repo/semantics/article

article
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