Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers.


Autoria(s): Bussien J.P.; Biollaz J.; Waeber B.; Nussberger J.; Turini G.A.; Brunner H.R.; Brunner-Ferber F.; Gomez H.J.; Otterbein E.S.
Data(s)

1986

Resumo

Synthetic atrial natriuretic peptide, containing 26 amino acids in the rat sequence, L-364, 343 (Ileu-ANP), was infused intravenously at increasing rates (1-40 micrograms/min) into four normal volunteers. Mean intraarterial blood pressure decreased and heart rate increased in cumulative-dose-dependent fashion. Skin blood flow as measured with a laser Doppler device rose already with a cumulative dose of 55 micrograms Ileu-ANP and further rises were directly related to dose. The only side effects observed were those accompanying symptomatic hypotension at higher doses. These findings provide strong evidence that Ileu-ANP acts as a vasodilator in normal volunteers.

Identificador

http://serval.unil.ch/?id=serval:BIB_AD1030A96B17

isbn:0160-2446

pmid:2419688

doi:10.1097/00005344-198601000-00031

isiid:A1986AYM0700031

Idioma(s)

en

Fonte

Journal of cardiovascular pharmacology, vol. 8, no. 1, pp. 216-20

Palavras-Chave #Adult; Atrial Natriuretic Factor; Blood Pressure; Heart Rate; Hemodynamics; Humans; Infusions, Parenteral; Male; Peptide Fragments; Regional Blood Flow; Skin
Tipo

info:eu-repo/semantics/article

article