Role of hepatitis C virus genotype 3 in liver fibrosis progression: a systematic review and meta-analysis.
Data(s) |
2011
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Resumo |
The progression of liver fibrosis in chronic hepatitis C has long been considered to be independent from viral genotypes. However, recent studies suggest an association between Hepatitis C virus (HCV) genotype 3 and accelerated liver disease progression. We completed a systematic review and meta-analysis of studies evaluating the association between HCV genotypes and fibrosis progression. PubMed, Embase and ISI Web of Knowledge databases were searched for cohort, cross-sectional and case-control studies on treatment-naïve HCV-infected adults in which liver fibrosis progression rate (FPR) was assessed by the ratio of fibrosis stage in one single biopsy to the duration of infection (single-biopsy studies) or from the change in fibrosis stage between two biopsies (paired biopsies studies). A random effect model was used to derive FPR among different HCV genotypes. Eight single-biopsy studies (3182 patients, mean/median duration of infection ranging from 9 to 21 years) and eight paired biopsies studies (mean interval between biopsies 2-12 years) met the selection criteria. The odds ratio for the association of genotype 3 with accelerated fibrosis progression was 1.52 (95% CI 1.12-2.07, P = 0.007) in single-biopsy studies and 1.37 (95% CI 0.87-2.17, P = 0.17) in paired biopsy studies. In conclusion, viral genotype 3 was associated with faster fibrosis progression in single-biopsy studies. This observation may have important consequences on the clinical management of genotype 3-infected patients. The association was not significant in paired biopsies studies, although the latter may be limited by important indication bias, short observation time and small sample size. |
Identificador |
http://serval.unil.ch/?id=serval:BIB_AA2D2FB79225 isbn:1365-2893 (Electronic) doi:10.1111/j.1365-2893.2011.01481.x isiid:000296464900001 pmid:21992794 |
Idioma(s) |
en |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Journal of Viral Hepatitis, vol. 18, no. 11, pp. 745-759 |
Palavras-Chave | #Biopsy; Case-Control Studies; Cohort Studies; Disease Progression; Genotype; Hepacivirus/genetics; Hepacivirus/pathogenicity; Hepatitis C, Chronic/genetics; Hepatitis C, Chronic/pathology; Humans; Liver/virology; Liver Cirrhosis/pathology; Liver Cirrhosis/virology; Odds Ratio; Risk Factors |
Tipo |
info:eu-repo/semantics/article article |