Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients.


Autoria(s): Hadaya K.; Ferrari-Lacraz S.; Giostra E.; Majno P.; Moll S.; Rubbia-Brandt L.; Marangon N.; Venetz J.P.; Bolle J.F.; Mentha G.; Villard J.
Data(s)

2009

Resumo

Combined liver-kidney transplantation is considered a low risk for immunologic complication. We report an unusual case of identical ABO liver-kidney recipient without preformed anti-human leukocyte antigen (HLA) antibodies, transplanted across a T- and B-cell-negative cross-match and complicated by early acute humoral and cellular rejection, first in the liver then in the kidney. While analyzing the immunologic complications in our cohort of 12 low-risk combined liver-kidney recipients, only one recipient experienced a rejection episode without detection of anti-HLA antibody over time. Although humoral or cellular rejection is rare after combined kidney-liver transplantation, our data suggest that even in low-risk recipients, the liver does not always systematically protect the kidney from acute rejection. Indeed, the detection of C4d in the liver should be carefully followed after combined liver-kidney transplantation.

Identificador

http://serval.unil.ch/?id=serval:BIB_A60BD946667A

isbn:0934-0874

pmid:18954373

doi:10.1111/j.1432-2277.2008.00775.x

isiid:000262288700014

Idioma(s)

en

Fonte

Transplant International, vol. 22, no. 2, pp. 242-246

Palavras-Chave #ABO Blood-Group System/immunology; Adult; Complement C4b/immunology; Female; Graft Rejection/drug therapy; Graft Rejection/immunology; Histocompatibility Testing; Humans; Immunosuppressive Agents/therapeutic use; Kidney Transplantation/adverse effects; Kidney Transplantation/immunology; Liver Transplantation/adverse effects; Liver Transplantation/immunology; Male; Peptide Fragments/immunology; Treatment Outcome
Tipo

info:eu-repo/semantics/article

article