Biocompatibility of an x-shaped zirconium implant in deep sclerectomy in rabbits
Contribuinte(s) |
Mermoud A. |
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Data(s) |
2009
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Resumo |
ABSTRACT : Background : The aim of this study was to evaluate the midterm biocompatibility of a new x-shaped implant made of zirconium in an animal model of glaucoma surgery. Methods : Preoperatively, ultrasound biomicroscopy (UBM), intraocular pressure (IOP) and outflow facility (OF) data were acquired. Upon surgery, one eye was chosen randomly to receive an implant, while the other received none. Ten rabbits went through a 1-, 2-, 3-, 4- and 6-month follow-up. [OP was measured regularly, UBM performed at 1, 3 and 6 months after surgery. At the end of the follow-up, OF was again measured. Histology sections were analyzed. Results : For both groups IOP control was satisfactory, while OF initially increased at month 1 to resume preoperative values thereafter. Eyes with implants had larger filtration blebs which decreased faster than in eyes without the implant. Drainage vessel density, inflammatory cell number and fibrosis were higher in tissues near the implant. Conclusions : The zirconium implant initially promoted the positive effects of the surgery (IOP control, OF increase). Nevertheless, after several months, foreign body reactions and fibrosis had occurred on some implants that restrained the early benefit of such a procedure. Modifications of the zirconium implant geometry could enhance the overall success rate. |
Formato |
8 |
Identificador |
http://serval.unil.ch/?id=serval:BIB_A0448A4FF4BC http://my.unil.ch/serval/document/BIB_A0448A4FF4BC.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A0448A4FF4BC9 |
Idioma(s) |
en |
Publicador |
Faculté de biologie et de médecine Université de Lausanne UNIL - Bugnon Rue du Bugnon 21 - bureau 4111 CH-1015 Lausanne SUISSE: Université de Lausanne, Faculté de biologie et médecine |
Direitos |
info:eu-repo/semantics/openAccess |
Palavras-Chave | #Aqueous humour ; Drainage device ; Filtering surgery ; Glaucoma ; Tonometry ; Ultrasonography |
Tipo |
info:eu-repo/semantics/doctoralThesis phdthesis |