New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Autoria(s): Horikoshi M.; Yaghootkar H.; Mook-Kanamori D.O.; Sovio U.; Taal H.R.; Hennig B.J.; Bradfield J.P.; St Pourcain B.; Evans D.M.; Charoen P.; Kaakinen M.; Cousminer D.L.; Lehtimäki T.; Kreiner-Møller E.; Warrington N.M.; Bustamante M.; Feenstra B.; Berry D.J.; Thiering E.; Pfab T.; Barton S.J.; Shields B.M.; Kerkhof M.; van Leeuwen E.M.; Fulford A.J.; Kutalik Z.; Zhao J.H.; den Hoed M.; Mahajan A.; Lindi V.; Goh L.K.; Hottenga J.J.; Wu Y.; Raitakari O.T.; Harder M.N.; Meirhaeghe A.; Ntalla I.; Salem R.M.; Jameson K.A.; Zhou K.; Monies D.M.; Lagou V.; Kirin M.; Heikkinen J.; Adair L.S.; Alkuraya F.S.; Al-Odaib A.; Amouyel P.; Andersson E.A.; Bennett A.J.; Blakemore A.I.; Buxton J.L.; Dallongeville J.; Das S.; de Geus E.J.; Estivill X.; Flexeder C.; Froguel P.; Geller F.; Godfrey K.M.; Gottrand F.; Groves C.J.; Hansen T.; Hirschhorn J.N.; Hofman A.; Hollegaard M.V.; Hougaard D.M.; Hyppönen E.; Inskip H.M.; Isaacs A.; Jørgensen T.; Kanaka-Gantenbein C.; Kemp J.P.; Kiess W.; Kilpeläinen T.O.; Klopp N.; Knight B.A.; Kuzawa C.W.; McMahon G.; Newnham J.P.; Niinikoski H.; Oostra B.A.; Pedersen L.; Postma D.S.; Ring S.M.; Rivadeneira F.; Robertson N.R.; Sebert S.; Simell O.; Slowinski T.; Tiesler C.M.; Tönjes A.; Vaag A.; Viikari J.S.; Vink J.M.; Vissing N.H.; Wareham N.J.; Willemsen G.; Witte D.R.; Zhang H.; Zhao J.; Meta-Analyses of Glucose-; Insulin-related traits Consortium (MAGIC); Wilson J.F.; Wilson J.F.; Stumvoll M.; Prentice A.M.; Meyer B.F.; Pearson E.R.; Boreham C.A.; Cooper C.; Gillman M.W.; Dedoussis G.V.; Moreno L.A.; Pedersen O.; Saarinen M.; Mohlke K.L.; Boomsma D.I.; Saw S.M.; Lakka T.A.; Körner A.; Loos R.J.; Ong K.K.; Vollenweider P.; van Duijn C.M.; Koppelman G.H.; Hattersley A.T.; Holloway J.W.; Hocher B.; Heinrich J.; Power C.; Melbye M.; Guxens M.; Pennell C.E.; Bønnelykke K.; Bisgaard H.; Eriksson J.G.; Widén E.; Hakonarson H.; Uitterlinden A.G.; Pouta A.; Lawlor D.A.; Smith G.D.; Frayling T.M.; McCarthy M.I.; Grant S.F.; Jaddoe V.W.; Jarvelin M.R.; Timpson N.J.; Prokopenko I.; Freathy R.M.; Early Growth Genetics (EGG) Consortium
Data(s)

01/12/2013
Resumo

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Identificador

http://serval.unil.ch/?id=serval:BIB_9BEFC7CAA18D

isbn:1546-1718 (Electronic)

pmid:23202124

doi:10.1038/ng.2477

isiid:000313164100014
Idioma(s)

en
Fonte

Nature Genetics, vol. 45, no. 1, pp. 76-82
Palavras-Chave #Adult; Birth Weight/genetics; Blood Pressure/genetics; Body Height/genetics; Diabetes Mellitus, Type 2/genetics; Female; Fetal Development/genetics; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Tipo

info:eu-repo/semantics/article

article
Acesso ao item digital