The wound watch: an objective staging system for wounds in the diabetic (db/db) mouse model.


Autoria(s): Pietramaggiori G.; Scherer S.; Orgill D.P.
Data(s)

2013

Resumo

As in cancer biology, in wound healing there is a need for objective staging systems to decide for the best treatment and predictors of outcome. We developed in the diabetic (db/db) wound healing model, a staging system, the "wound watch," based on the quantification of angiogenesis and cell proliferation in open wounds. In chronic wounds, there is often a lack of cellular proliferation and angiogenesis that leads to impaired healing. The wound watch addresses this by quantifying the proliferative phase of wound healing in two dimensions (cellular division and angiogenesis). The results are plotted in a two-dimensional graph to monitor the course of healing and compare the response to different treatments.

Identificador

https://serval.unil.ch/?id=serval:BIB_996D68397270

isbn:1940-6029 (Electronic)

pmid:24029939

doi:10.1007/978-1-62703-505-7_13

isiid:000325609000014

Idioma(s)

en

Fonte

Methods in Molecular Biology, vol. 1037, pp. 245-254

Palavras-Chave #Animals; Biological Markers/metabolism; Diabetes Complications; Disease Models, Animal; Immunohistochemistry/methods; Mice; Wound Healing; Wounds and Injuries/etiology; Wounds and Injuries/metabolism
Tipo

info:eu-repo/semantics/article

article