Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.
| Data(s) |
2002
|
|---|---|
| Resumo |
While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degrees C but not at 4 degrees C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_9803E7334361 isbn:0066-4804 (Print) pmid:12384385 doi:10.1128/AAC.46.11.3654-3656.2002 isiid:000178712800053 |
| Idioma(s) |
en |
| Fonte |
Antimicrobial Agents and Chemotherapy, vol. 46, no. 11, pp. 3654-3656 |
| Palavras-Chave | #Cephalosporins/blood; Cephalosporins/chemistry; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Temperature; Ultrafiltration |
| Tipo |
info:eu-repo/semantics/article article |
