Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin-ruthenium metalla-cubes.


Autoria(s): Schmitt F.; Barry N.P.; Juillerat-Jeanneret L.; Therrien B.
Data(s)

2012

Resumo

Two cationic octanuclear metalla-cubes [Ru(8)(η(6)-C(6)H(5)Me)(8)(tpp-H2)(2)(dhbq)(4)](8+) and [Ru(8)(η(6)-p-iPrC(6)H(4)Me)(8)(tpp-H2)(2)(dhbq)(4)](8+) were prepared and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1μM concentration, LD(50)=2-7J/cm(2)), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.

Identificador

https://serval.unil.ch/?id=serval:BIB_96CD25906190

isbn:1464-3405 (Electronic)

pmid:22153934

doi:10.1016/j.bmcl.2011.11.058

isiid:000298636700029

Idioma(s)

en

Fonte

Bioorganic and Medicinal Chemistry Letters, vol. 22, no. -, pp. 178-180

Tipo

info:eu-repo/semantics/article

article