Classification des leucémies aiguës par les marqueurs de surface et corrélation avec le diagnostic morphologique résultats sur 111 cas


Autoria(s): von Fliedner V.; Carrel S.; Morell A.; Heumann D.; Losa G.; Hirt A.; Jeannet M.; Mach J.P.; Cruchaud A.
Data(s)

1981

Resumo

111 patients with acute leukemia, including 29 children, were classified according to the surface markers and cytochemistry of their blasts. The acute leukemias were separated into two majors groups (lymphoid and non-lymphoid) depending on the presence or absence of specific lymphoid markers. On the basis of these criteria a correlation of 94% with the hematological diagnosis was obtained. Acute lymphoblastic leukemia (ALL) was divisible into three sub-groups: 11 cases expressing T-cell specific markers were classified as T-ALL and 33 cases expressing the common ALL antigen (CALLA) as c-ALL. 18 of the latter expressed an additional marker, DSA (Daudi surface antigen), splitting c-ALL cases in two subgroups. Cytochemistry of the cases lacking specific surface markers (n = 67) served to diagnose 41 acute myeloid leukemia (AML) cases and 8 monoblastic leukemias. The remaining 18 cases could not be classified. The presence of absence of HLD-DR (Ia) antigens served to subdivide AML into two major subgroups. The prognostic significance of these new diagnostic splits is under active study.

Identificador

http://serval.unil.ch/?id=serval:BIB_914BCAD41666

isbn:0036-7672 (Print)

pmid:6975992

isiid:A1981MJ84800006

Idioma(s)

fr

Fonte

Schweizerische Medizinische Wochenschrift, vol. 111, no. 41, pp. 1524-1526

Palavras-Chave #Acute Disease; Antigens, Surface/analysis; B-Lymphocytes/immunology; HLA Antigens/analysis; Humans; Leukemia/classification; Leukemia/immunology; Receptors, Immunologic/analysis; Rosette Formation; T-Lymphocytes/immunology
Tipo

info:eu-repo/semantics/article

article