Atrial natriuretic peptide administered as intravenous infusion or bolus injection to patients with liver cirrhosis and ascites.


Autoria(s): Petrillo A.; Scherrer U.; Gonvers J.J.; Nussberger J.; Marder H.; de Vane P.; Waeber B.; Hofstetter J.R.; Brunner H.R.
Data(s)

1988

Resumo

The effect of a synthetic atrial natriuretic peptide (h-ANP, 25 amino acids, Wy-47.663) on blood pressure, renal electrolyte excretion, plasma catecholamines, and plasma renin activity was studied in nine patients with cirrhosis of the liver and ascites. The peptide was infused intravenously at 24-h intervals for 2 h in groups of four patients each in two different doses (0.015 and 0.075 micrograms/kg/min or 0.06 and 0.3 micrograms/kg/min). A control experiment with the vehicle was performed in all patients. In three patients h-ANP (1 and 2 micrograms/kg i.v.) was administered as an intravenous bolus injection. Consistent falls in blood pressure were observed during h-ANP infusion only with the two higher doses. The two lower infused doses induced a consistent natriuresis; this renal response was abolished when the two larger doses were used. When given as a bolus, h-ANP had a natriuretic effect comparable to that of the two lower doses of infused h-ANP. Plasma catecholamines and plasma renin activity increased during infusion of the two higher doses of h-ANP. It thus appears that in patients with cirrhosis and ascites, the natriuretic effect of infused h-ANP decreases rather than increases when the doses are raised. Bolus administration of h-ANP may be less prone to trigger counterbalancing responses and side-effects.

Identificador

http://serval.unil.ch/?id=serval:BIB_8E88887C6EA7

isbn:0160-2446

pmid:2464099

doi:10.1097/00005344-198809000-00004

isiid:A1988P833000004

Idioma(s)

en

Fonte

Journal of cardiovascular pharmacology, vol. 12, no. 3, pp. 279-85

Palavras-Chave #Adult; Atrial Natriuretic Factor; Blood Pressure; Catecholamines; Electrolytes; Female; Heart Rate; Hematocrit; Hormones; Humans; Infusions, Intravenous; Liver Cirrhosis; Male; Middle Aged
Tipo

info:eu-repo/semantics/article

article