Toll-like receptor 3 is necessary for dsRNA adjuvant effects.


Autoria(s): Salaun B.; Greutert M.; Romero P.
Data(s)

2009

Resumo

Toll-like receptors (TLR) recognize pathogen associated molecular patterns, and the binding of their specific ligands triggers a proinflammatory response that helps to fight invading microorganisms, and can be harnessed to increase vaccine efficiency. The present study demonstrates that double-stranded RNA is a promising vaccine adjuvant able to increase both proliferation and activation of antigen-specific CD8(+) T cells. Importantly, TLR3 is required for this adjuvant effect, as TLR3 deficient recipients failed to enhance proliferation of adoptively transferred TCR transgenic CD8(+) T cells in the presence of double-stranded RNA. Finally, this study also shows that, in contrast to previous reports in humans, TLR3 does not exert direct costimulatory activity on CD8(+) T cells in mice.

Identificador

http://serval.unil.ch/?id=serval:BIB_87C8151EB0EB

isbn:0264-410X

pmid:19195489

doi:10.1016/j.vaccine.2009.01.044

isiid:000264680600008

Idioma(s)

en

Fonte

Vaccine, vol. 27, no. 12, pp. 1841-1847

Palavras-Chave #Adjuvants, Immunologic; Adsorption; Aluminum Hydroxide; Animals; Antibodies, Anti-Idiotypic; Body Temperature; DNA; Ethylene Glycols; Extracellular Fluid; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Isoelectric Focusing; Mice; Sheep; Thermodynamics; Toll-Like Receptor 3; Vaccines
Tipo

info:eu-repo/semantics/article

article