T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.


Autoria(s): Launois P.; Drowart A.; Bourreau E.; Couppie P.; Farber C.M.; Van Vooren J.P.; Huygen K.
Data(s)

2011

Resumo

The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen.

Identificador

https://serval.unil.ch/?id=serval:BIB_83944FED4C41

isbn:1740-2530 (Electronic)

pmid:20936150

doi:10.1155/2011/640309

isiid:000283222100001

http://my.unil.ch/serval/document/BIB_83944FED4C41.pdf

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_83944FED4C414

Idioma(s)

en

Direitos

info:eu-repo/semantics/openAccess

Fonte

Clinical and Developmental Immunology, vol. 2011, pp. 1-10

Palavras-Chave #AIDS-Related Opportunistic Infections/immunology; AIDS-Related Opportunistic Infections/microbiology; Acyltransferases/immunology; Antigens, Bacterial/immunology; Belgium; French Guiana; HIV/physiology; HIV Infections/complications; HIV Infections/immunology; Humans; Immunologic Memory; Interferon-gamma/metabolism; Lymphocyte Activation/immunology; Mycobacterium Infections/complications; Mycobacterium Infections/immunology; Mycobacterium tuberculosis/immunology; T-Lymphocytes/immunology; Tuberculin Test; Tuberculosis/complications; Tuberculosis/immunology; Tuberculosis, Pulmonary/complications; Tuberculosis, Pulmonary/immunology
Tipo

info:eu-repo/semantics/article

article