T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.
Data(s) |
2011
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Resumo |
The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen. |
Identificador |
https://serval.unil.ch/?id=serval:BIB_83944FED4C41 isbn:1740-2530 (Electronic) pmid:20936150 doi:10.1155/2011/640309 isiid:000283222100001 http://my.unil.ch/serval/document/BIB_83944FED4C41.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_83944FED4C414 |
Idioma(s) |
en |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Clinical and Developmental Immunology, vol. 2011, pp. 1-10 |
Palavras-Chave | #AIDS-Related Opportunistic Infections/immunology; AIDS-Related Opportunistic Infections/microbiology; Acyltransferases/immunology; Antigens, Bacterial/immunology; Belgium; French Guiana; HIV/physiology; HIV Infections/complications; HIV Infections/immunology; Humans; Immunologic Memory; Interferon-gamma/metabolism; Lymphocyte Activation/immunology; Mycobacterium Infections/complications; Mycobacterium Infections/immunology; Mycobacterium tuberculosis/immunology; T-Lymphocytes/immunology; Tuberculin Test; Tuberculosis/complications; Tuberculosis/immunology; Tuberculosis, Pulmonary/complications; Tuberculosis, Pulmonary/immunology |
Tipo |
info:eu-repo/semantics/article article |