Biblioteca Digital

**Autoria(s):** Miró J.M.; Entenza J.M.; Del Río A.; Velasco M.; Castañeda X.; Garcia de la Mària C.; Giddey M.; Armero Y.; Pericàs J.M.; Cervera C.; Mestres C.A.; Almela M.; Falces C.; Marco F.; Moreillon P.; Moreno A.; Hospital Clinic Experimental Endocarditis Study Group
Data(s)	2012
Resumo	We describe 3 patients with left-sided staphylococcal endocarditis (1 with methicillin-susceptible Staphylococcus aureus [MSSA] prosthetic aortic valve endocarditis and 2 with methicillin-resistant S. aureus [MRSA] native-valve endocarditis) who were successfully treated with high-dose intravenous daptomycin (10 mg/kg/day) plus fosfomycin (2 g every 6 h) for 6 weeks. This combination was tested in vitro against 7 MSSA, 5 MRSA, and 2 intermediately glycopeptide-resistant S. aureus isolates and proved to be synergistic against 11 (79%) strains and bactericidal against 8 (57%) strains. This combination deserves further clinical study.
Identificador	http://serval.unil.ch/?id=serval:BIB_7B56DF392269 isbn:1098-6596 (Electronic) pmid:22644033 doi:10.1128/AAC.06449-11 isiid:000306826300066
Idioma(s)	en
Fonte	Antimicrobial Agents and Chemotherapy, vol. 56, no. 8, pp. 4511-4515
Palavras-Chave	#Aged; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/adverse effects; Daptomycin/administration & dosage; Daptomycin/adverse effects; Drug Synergism; Drug Therapy, Combination; Endocarditis, Bacterial/drug therapy; Female; Fosfomycin/administration & dosage; Fosfomycin/adverse effects; Humans; Male; Methicillin-Resistant Staphylococcus aureus/drug effects; Microbial Sensitivity Tests; Middle Aged; Staphylococcal Infections/drug therapy; Staphylococcal Infections/microbiology
Tipo	info:eu-repo/semantics/article article

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