Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
| Data(s) |
2009
|
|---|---|
| Resumo |
Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_7ACD5EDBDF55 isbn:1879-0445[electronic] pmid:19321146 doi:10.1016/j.cub.2009.02.011 isiid:000264616200018 |
| Idioma(s) |
en |
| Fonte |
Current biology, vol. 19, no. 6, pp. R262-R265 |
| Palavras-Chave | #Antiviral Agents; Biosensing Techniques; Carrier Proteins/genetics; DNA/genetics; DNA-Binding Proteins/genetics; Humans; Immunity, Innate/genetics; Inflammation/genetics; Inflammation/immunology; Interferons/genetics; Interleukin-1beta/immunology; Nuclear Proteins/immunology |
| Tipo |
info:eu-repo/semantics/article article |
