Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
| Data(s) |
2005
|
|---|---|
| Resumo |
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_7751028C2219 isbn:0066-4804[print], 0066-4804[linking] pmid:16251333 doi:10.1128/AAC.49.11.4789-4792.2005 isiid:000233020900055 |
| Idioma(s) |
en |
| Fonte |
Antimicrobial Agents and Chemotherapy, vol. 49, no. 11, pp. 4789-4792 |
| Palavras-Chave | #Animals; Cytokines/biosynthesis; Endocarditis, Bacterial/drug therapy; Endocarditis, Bacterial/microbiology; Enzymes/therapeutic use; Pneumococcal Infections/drug therapy; Pneumococcal Infections/microbiology; Rats |
| Tipo |
info:eu-repo/semantics/article article |
