On circuit functionality in boolean networks.


Autoria(s): Comet J.P.; Noual M.; Richard A.; Aracena J.; Calzone L.; Demongeot J.; Kaufman M.; Naldi A.; Snoussi el H; Thieffry D.
Data(s)

2013

Resumo

It has been proved, for several classes of continuous and discrete dynamical systems, that the presence of a positive (resp. negative) circuit in the interaction graph of a system is a necessary condition for the presence of multiple stable states (resp. a cyclic attractor). A positive (resp. negative) circuit is said to be functional when it "generates" several stable states (resp. a cyclic attractor). However, there are no definite mathematical frameworks translating the underlying meaning of "generates." Focusing on Boolean networks, we recall and propose some definitions concerning the notion of functionality along with associated mathematical results.

Identificador

http://serval.unil.ch/?id=serval:BIB_75F51380A25E

isbn:1522-9602 (Electronic)

pmid:23504387

doi:10.1007/s11538-013-9829-2

isiid:000321220400003

Idioma(s)

en

Fonte

Bulletin of Mathematical Biology, vol. 75, no. 6, pp. 906-919

Tipo

info:eu-repo/semantics/article

article