IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.
| Data(s) |
2010
|
|---|---|
| Resumo |
IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_72BA2B267468 isbn:1091-6490 (Electronic) pmid:20133862 doi:10.1073/pnas.0909384107 isiid:000274296300067 |
| Idioma(s) |
en |
| Fonte |
Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 5, pp. 2171-2176 |
| Palavras-Chave | #Animals; Antibodies, Blocking/administration & dosage; Antigen-Antibody Complex/metabolism; Half-Life; Homeostasis; Immunoglobulin G/metabolism; Interleukin-2/immunology; Interleukin-2/metabolism; Interleukin-2 Receptor alpha Subunit/antagonists & inhibitors; Interleukin-2 Receptor alpha Subunit/deficiency; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Receptors, Fc/metabolism; Recombinant Fusion Proteins/immunology; Recombinant Fusion Proteins/metabolism |
| Tipo |
info:eu-repo/semantics/article article |
