Histone H1 regulates chromatin condensation in Leishmania parasites.
| Data(s) |
2007
|
|---|---|
| Resumo |
We investigated the functional role of the Leishmania histone H1 and demonstrate for the first time that addition of histone H1 has a strong effect on microccocal digestion, chromatin condensation of parasite nuclei and that its overexpression can modulate parasite infectivity in vivo. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_721FF45AC3A7 isbn:0014-4894 (Print) pmid:17207482 doi:10.1016/j.exppara.2006.11.002 isiid:000246219200011 |
| Idioma(s) |
en |
| Fonte |
Experimental Parasitology, vol. 116, no. 1, pp. 83-87 |
| Palavras-Chave | #Animals; Cell Line; Chromatin/metabolism; Gene Expression; Histones/genetics; Histones/physiology; Leishmania major/chemistry; Leishmania major/pathogenicity; Leishmaniasis, Cutaneous/parasitology; Macrophages/parasitology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Signal Transduction; Transfection; Virulence |
| Tipo |
info:eu-repo/semantics/article article |
