Evaluation de l'efficacite antihypertensive de l'isradipine SRO par enregistrement tensionnel en ambulatoire. [Evaluation of the antihypertensive efficacy of isradipine SRO as assessed by ambulatory blood pressure determination]


Autoria(s): Waeber B.; Soret P.; Poget P. N.; Brunner H. R.
Data(s)

1992

Resumo

The calcium channel blocker isradipine has become recently available in a form with delayed release (isradipine SRO). The anti-hypertensive efficacy and tolerance of this preparation at a single daily dose of 5 mg was studied in 40 patients with uncomplicated essential hypertension over a period of 6 weeks. Blood pressure during office visits decreased under Isradipine SRO from 164/105 +/- 16/7 to 144/93 +/- 12/7 mmHg (mean +/- 1 standard deviation p < 0.001). Using ambulatory blood pressure recording we could show that antihypertensive efficacy of the new galenic form persisted over 24 hours. During the day the blood pressure dropped from 150/95 +/- 13/7 to 141/91 +/- 13/7 mmHg (p < 0.001), during the night from 131/85 +/- 13/3 to 121/81 +/- 15/9 mmHg (p < 0.001). Heart-rate was not changed by treatment and the drug was well tolerated. Isradipine SRO at a single dose is thus well suited for antihypertensive treatment.

Identificador

http://serval.unil.ch/?id=serval:BIB_719445568FD0

pmid:1465521

isbn:1013-2058

Idioma(s)

fr

Fonte

Schweizerische Rundschau fur Medizin Praxis, vol. 81, no. 50, pp. 1514-1517

Palavras-Chave #AdultAgedBlood Pressure/drug effectsDelayed-Action PreparationsFemaleHumansHypertension/*drug therapy/physiopathologyIsradipine/administration & dosage/*therapeutic useMaleMiddle AgedSingle-Blind Method
Tipo

info:eu-repo/semantics/article

article