Structural and functional properties of genes involved in human cancer


Autoria(s): Furney, Simon J.; Higgins, Desmond G.; Ouzounis, Christos A.; López Bigas, Núria
Data(s)

02/07/2013

Resumo

Background: One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer.Results: We have conducted an analysis of a set of genes known to be involved in cancer in order to unveil their unique features that can assist towards the identification of new candidate cancer genes. Conclusion: We have detected key patterns in this group of genes in terms of the molecular function or the biological process in which they are involved as well as sequence properties. Based on these features we have developed an accurate Bayesian classification model with which human genes have been scored for their likelihood of involvement in cancer.

Identificador

http://hdl.handle.net/10230/16420

Idioma(s)

eng

Publicador

BioMed Central

Direitos

(c) 2006 Furney et al. Creative Commons Attribution License

info:eu-repo/semantics/openAccess

<a href="http://creativecommons.org/licenses/by/2.0/">http://creativecommons.org/licenses/by/2.0/</a>

Palavras-Chave #Càncer -- Aspectes genètics #Genètica molecular
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion