NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.


Autoria(s): Yamamoto, H.; Williams, E.G.; Mouchiroud, L.; Cantó, C.; Fan, W.; Downes, M.; Héligon, C.; Barish, G.D.; Desvergne, B.; Evans, R.M.; Schoonjans, K.; Auwerx, J.
Data(s)

2011

Resumo

Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity. The activation of selected transcription factors that control muscle function, such as MEF2, PPARβ/δ, and ERRs, underpins these phenotypic alterations. NCoR1 levels are decreased in conditions that require fat oxidation, resetting transcriptional programs to boost oxidative metabolism. Knockdown of gei-8, the sole C. elegans NCoR homolog, also robustly increased muscle mitochondria and respiration, suggesting conservation of NCoR1 function. Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function.

Identificador

https://serval.unil.ch/notice/serval:BIB_5C22DA50B7A1

info:pmid:22078881

https://serval.unil.ch/resource/serval:BIB_5C22DA50B7A1.P001/REF

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_5C22DA50B7A12

urn:nbn:ch:serval-BIB_5C22DA50B7A12

Idioma(s)

eng

Fonte

Cell1474827-839

Palavras-Chave #Animals; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Gene Deletion; Gene Knockdown Techniques; Humans; Mice; Mitochondria, Muscle/metabolism; Muscle Development; Muscle, Skeletal/metabolism; Nuclear Receptor Co-Repressor 1/genetics; Nuclear Receptor Co-Repressor 1/metabolism; PPAR delta/metabolism; PPAR-beta/metabolism; Physical Conditioning, Animal
Tipo

info:eu-repo/semantics/article

article

Formato

application/pdf

Direitos

info:eu-repo/semantics/openAccess

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