Transforming growth factor-beta: the breaking open of a black box.


Autoria(s): Alevizopoulos A.; Mermod N.
Data(s)

01/07/1997

Resumo

Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases.

Identificador

http://serval.unil.ch/?id=serval:BIB_5B8C3494D769

isbn:0265-9247[print], 0265-9247[linking]

pmid:9230691

doi:10.1002/bies.950190709

isiid:A1997XK26200008

Idioma(s)

en

Fonte

Bioessays, vol. 19, no. 7, pp. 581-591

Palavras-Chave #Animals; Cell Communication/physiology; Cell Cycle/physiology; Cell Differentiation/physiology; Gene Expression Regulation/physiology; Humans; Immunologic Factors/therapeutic use; Multigene Family; Neoplasms/therapy; Organ Specificity; Receptors, Transforming Growth Factor beta/chemistry; Receptors, Transforming Growth Factor beta/classification; Signal Transduction/genetics; Signal Transduction/physiology; Transforming Growth Factor beta/chemistry; Transforming Growth Factor beta/genetics; Vertebrates/genetics; Vertebrates/physiology
Tipo

info:eu-repo/semantics/review

article