Transforming growth factor-beta: the breaking open of a black box.
Data(s) |
01/07/1997
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Resumo |
Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases. |
Identificador |
http://serval.unil.ch/?id=serval:BIB_5B8C3494D769 isbn:0265-9247[print], 0265-9247[linking] pmid:9230691 doi:10.1002/bies.950190709 isiid:A1997XK26200008 |
Idioma(s) |
en |
Fonte |
Bioessays, vol. 19, no. 7, pp. 581-591 |
Palavras-Chave | #Animals; Cell Communication/physiology; Cell Cycle/physiology; Cell Differentiation/physiology; Gene Expression Regulation/physiology; Humans; Immunologic Factors/therapeutic use; Multigene Family; Neoplasms/therapy; Organ Specificity; Receptors, Transforming Growth Factor beta/chemistry; Receptors, Transforming Growth Factor beta/classification; Signal Transduction/genetics; Signal Transduction/physiology; Transforming Growth Factor beta/chemistry; Transforming Growth Factor beta/genetics; Vertebrates/genetics; Vertebrates/physiology |
Tipo |
info:eu-repo/semantics/review article |