Genetic loci influencing kidney function and chronic kidney disease.

Autoria(s): Chambers J.C.; Zhang W.; Lord G.M.; van der Harst P.; Lawlor D.A.; Sehmi J.S.; Gale D.P.; Wass M.N.; Ahmadi K.R.; Bakker S.J.; Beckmann J.; Bilo H.J.; Bochud Murielle; Brown M.J.; Caulfield M.J.; Connell J.M.; Cook H.T.; Cotlarciuc I.; Davey Smith G.; de Silva R.; Deng G.; Devuyst O.; Dikkeschei L.D.; Dimkovic N.; Dockrell M.; Dominiczak A.; Ebrahim S.; Eggermann T.; Farrall M.; Ferrucci L.; Floege J.; Forouhi N.G.; Gansevoort R.T.; Han X.; Hedblad B.; Homan van der Heide J.J.; Hepkema B.G.; Hernandez-Fuentes M.; Hypponen E.; Johnson T.; de Jong P.E.; Kleefstra N.; Lagou V.; Lapsley M.; Li Y.; Loos R.J.; Luan J.; Luttropp K.; Maréchal C.; Melander O.; Munroe P.B.; Nordfors L.; Parsa A.; Peltonen L.; Penninx B.W.; Perucha E.; Pouta A.; Prokopenko I.; Roderick P.J.; Ruokonen A.; Samani N.J.; Sanna S.; Schalling M.; Schlessinger D.; Schlieper G.; Seelen M.A.; Shuldiner A.R.; Sjögren M.; Smit J.H.; Snieder H.; Soranzo N.; Spector T.D.; Stenvinkel P.; Sternberg M.J.; Swaminathan R.; Tanaka T.; Ubink-Veltmaat L.J.; Uda M.; Vollenweider P.; Wallace C.; Waterworth D.; Zerres K.; Waeber G.; Wareham N.J.; Maxwell P.H.; McCarthy M.I.; Jarvelin M.R.; Mooser V.; Abecasis G.R.; Lightstone L.; Scott J.; Navis G.; Elliott P.; Kooner J.S.
Data(s)

2010
Resumo

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Identificador

http://serval.unil.ch/?id=serval:BIB_55509FC8B9C3

isbn:1546-1718[electronic], 1061-4036[linking]

pmid:20383145

doi:10.1038/ng.566

isiid:000277179500005
Idioma(s)

en
Direitos

info:eu-repo/semantics/openAccess
Fonte

Nature Genetics, vol. 42, no. 5, pp. 373-375
Palavras-Chave #Biological Transport; Creatinine/blood; Cystatin C/metabolism; Type="Geographic">Europe; Gene Expression Regulation; Genetic Markers/genetics; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Genotype; Glomerular Filtration Rate; Humans; Kidney/physiology; Kidney Failure, Chronic/genetics; Kidney Failure, Chronic/pathology; Models, Genetic ; Colaus Study
Tipo

info:eu-repo/semantics/article

article
Acesso ao item digital