Radiolabeling of monoclonal antibody against carcinoembryonic antigen with 88Y and biodistribution studies.


Autoria(s): Buchsbaum D.J.; Hanna D.E.; Randall B.C.; Buchegger F.; Mach J.P.
Data(s)

1985

Resumo

The biodistribution of the 202 monoclonal antibody against CEA labeled with 88Y by the bicyclic DTPA anhydride method was studied in normal Balb/c mice. The in vitro binding to 1 X 10(7) CO112, LS174T and WiDR colon cancer cells was 21.0, 27.3 and 18.8%, respectively. The binding to an equal number of KM-3 leukemia cells and normal human lymphocytes was 8.9 and 3.2%, respectively. Liver, spleen, kidney and blood were the tissues that showed the highest uptake of radiolabeled antibody in vivo.

Identificador

http://serval.unil.ch/?id=serval:BIB_536D4A4DFBC3

isbn:0969-8051 and 0047-0740 (Print)

pmid:2412985

doi:10.1016/0047-0740(85)90160-3

isiid:A1985AMU2300001

Idioma(s)

en

Fonte

International Journal of Nuclear Medicine and Biology, vol. 12, no. 2, pp. 79-82

Palavras-Chave #Animals; Antibodies, Monoclonal; Carcinoembryonic Antigen/analysis; Carcinoembryonic Antigen/immunology; Cell Line; Colonic Neoplasms; Epitopes/analysis; Immunoassay; Kinetics; Leukemia; Mice; Mice, Inbred BALB C; Tissue Distribution; Yttrium Radioisotopes/diagnostic use
Tipo

info:eu-repo/semantics/article

article