Administration intra-vitréenne de liposomes pour la vectorisation de principes actifs [The use of liposomes as intravitreal drug delivery system].


Autoria(s): Bejjani R.A.; Jeanny J.C.; Bochot A.; Behar-Cohen F.
Data(s)

2003

Resumo

Liposomes are vesicular lipidic systems allowing encapsulation of drugs. This article reviews the relevant issues in liposome structure (composition and size), and their influence on intravitreal pharmacokinetics. Liposome-mediated drug delivery to the posterior segment of the eye via intravitreal administration has been addressed by several authors and remains experimental. Liposomes have been used for intravitreal delivery of antibiotics, antivirals, antifungal drugs, antimetabolites, and cyclosporin. Encapsulation of these drugs within liposomes markedly increased their intravitreal half-life, and reduced their retinal toxicity. Liposomes have also shown an attractive potential for retinal gene transfer by intravitreal delivery of plasmids or oligonucleotides.

Identificador

https://serval.unil.ch/?id=serval:BIB_4ED717C46031

isbn:0181-5512 (Print)

pmid:14631286

isiid:000187840700014

doi:

Idioma(s)

fr

Fonte

Journal Français D'ophtalmologie, vol. 26, no. 9, pp. 981-985

Palavras-Chave #Administration, Topical; Biological Availability; Blood-Retinal Barrier; Drug Delivery Systems/methods; Gene Transfer Techniques; Half-Life; Humans; Liposomes/administration & dosage; Liposomes/chemistry; Metabolic Clearance Rate; Vitreous Body/drug effects; Vitreous Body/metabolism
Tipo

info:eu-repo/semantics/review

article