Epigenetic mechanisms in non-alcoholic fatty liver disease: An emerging field.


Autoria(s): Gallego-Durán, Rocío; Romero-Gómez, Manuel
Data(s)

14/01/2016

14/01/2016

28/10/2015

Resumo

Non-alcoholic fatty liver disease (NAFLD) is an emerging health concern in both developed and non-developed world, encompassing from simple steatosis to non-alcoholic steatohepatitis (NASH), cirrhosis and liver cancer. Incidence and prevalence of this disease are increasing due to the socioeconomic transition and change to harmful diet. Currently, gold standard method in NAFLD diagnosis is liver biopsy, despite complications and lack of accuracy due to sampling error. Further, pathogenesis of NAFLD is not fully understood, but is well-known that obesity, diabetes and metabolic derangements played a major role in disease development and progression. Besides, gut microbioma and host genetic and epigenetic background could explain considerable interindividual variability. Knowledge that epigenetics, heritable events not caused by changes in DNA sequence, contribute to development of diseases has been a revolution in the last few years. Recently, evidences are accumulating revealing the important role of epigenetics in NAFLD pathogenesis and in NASH genesis. Histone modifications, changes in DNA methylation and aberrant profiles or microRNAs could boost development of NAFLD and transition into clinical relevant status. PNPLA3 genotype GG has been associated with a more progressive disease and epigenetics could modulate this effect. The impact of epigenetic on NAFLD progression could deserve further applications on therapeutic targets together with future non-invasive methods useful for the diagnosis and staging of NAFLD.

Journal Article;

Supported by European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement, No. HEALTH-F2-2009-241762 for the project FLIP; and Consejería de Salud de la Junta de Andalucía, No. PI-0488/2012.

Identificador

Gallego-Durán R, Romero-Gómez M. Epigenetic mechanisms in non-alcoholic fatty liver disease: An emerging field. World J Hepatol. 2015 ; 7(24):2497-502

1948-5182 (Online)

PMC4621463

http://hdl.handle.net/10668/2128

26523202

10.4254/wjh.v7.i24.2497

Idioma(s)

en

Publicador

Baishideng Publishing Group Co. Limited

Relação

World Journal of Hepatology

http://www.wjgnet.com/1948-5182/abstract/v7/i24/2497.htm

Direitos

Acceso abierto

Palavras-Chave #Non-alcoholic steatohepatitis #Epigenetics #Diagnosis #Treatment #Non-alcoholic fatty liver disease #Secuencia de bases #Diabetes Mellitus #Hígado graso #Cirrosis hepática #Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Base Sequence #Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA #Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus #Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet #Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver #Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype #Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Amino Acid Sequence::Histone Code #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence #Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosis #Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Alkylation::Methylation #Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence #Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Bias (Epidemiology)::Selection Bias #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/published

Editorial