Prognosis Relevance of Serum Cytokines in Pancreatic Cancer.
| Data(s) |
27/11/2015
27/11/2015
2015
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|---|---|
| Resumo |
The overall survival of patients with pancreatic ductal adenocarcinoma is extremely low. Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in patients with pancreatic cancer and to establish a practical prognosis index that significantly predicts patients' outcomes. We have conducted an extensive analysis of serum prognosis biomarkers using an antibody array comprising 507 human cytokines. Overall survival was estimated using the Kaplan-Meier method. Univariate and multivariate Cox's proportional hazard models were used to analyze prognosis factors. To determine the extent that survival could be predicted based on this index, we used the leave-one-out cross-validation model. The multivariate model showed a better performance and it could represent a novel panel of serum cytokines that correlates to poor prognosis in pancreatic cancer. B7-1/CD80, EG-VEGF/PK1, IL-29, NRG1-beta1/HRG1-beta1, and PD-ECGF expressions portend a poor prognosis for patients with pancreatic cancer and these cytokines could represent novel therapeutic targets for this disease. Journal Article; The study was fully supported by ROCHE FARMA S.A (ref.H/OH-TAR-10/131 and ref. H/OH-TRR-08/59) and Instituto de Salud Carlos III (ISCIII) (Clinical trial ref. EC08/00009),and the Government of Andalusia Project P12-TIC-2082 |
| Identificador |
Torres C, Linares A, Alejandre MJ, Palomino-Morales RJ, Caba O, Prados J, et al. Prognosis Relevance of Serum Cytokines in Pancreatic Cancer. Biomed Res Int; 2015:518284 2314-6141 (Online) PMC4539422 http://hdl.handle.net/10668/2089 26346854 10.1155/2015/518284 |
| Idioma(s) |
en |
| Publicador |
Hindawi Publishing Corporation |
| Relação |
BioMed research international http://www.hindawi.com/journals/bmri/2015/518284/abs/ |
| Direitos |
Acceso abierto |
| Palavras-Chave | #Marcadores biológicos #Carcinoma ductal pancreático #Citocinas #Desoxicitidina #Humanos #Neoplasias pancreáticas #Pronóstico #Modelos de riesgos proporcionales #Timidina fosforilasa #Factor de crecimiento endotelial vascular derivado de glándulas endocrinas #Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pancreatic Neoplasms::Carcinoma, Pancreatic Ductal #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines #Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidine Nucleosides::Cytidine::Deoxycytidine #Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasms #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models #Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Glycosyltransferases::Pentosyltransferases::Pyrimidine Phosphorylases::Thymidine Phosphorylase |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/published Artículo |
